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KMID : 0388020010120040318
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Korean Journal Gynecologic Oncology and Colposcopy
2001 Volume.12 No. 4 p.318 ~ p.324
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The Clinical Significance of Interleukin-6 Promoter Polymorphism in Cervical Cancer
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Kim Y.-J.
Moon Hye-Sung
Chung Hye-Won
Kim Seung-Cheol
Kim Hyung-Rae
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Abstract
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Objective: The aims of this study were to determine whether polymorphisms of the interleukin-6 promoter might be associated with an increased risk of cervical cancer.
Methods: The bloods were obtained from healthy women(n=130), and patients with cervical cancer(n=109). The IL-6 promoter was examined with allele-specific PCR method. The clinical characteristics of patients were compared between two groups.
Results: There is IL-6 -572 SNP. The genotypic distribution in cervical cancer patients were GG genotype 55(50.5%), GC genotype 45(41.3%), CC genotype 9(8.2%). There were no stastistical differences of each genotypes between control group and cervical cancer group.(p>0.05).
Conclusion: Our results suggested that SNP of IL-6 promoter is not related with the carcinogenesis of cervical cancer.
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KEYWORD
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Interleukin-6 promoter, Single nucleotide polymorphism, Cervix cancer
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